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Cannabinoids and the Brain$
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Linda A. Parker

Print publication date: 2017

Print ISBN-13: 9780262035798

Published to MIT Press Scholarship Online: September 2017

DOI: 10.7551/mitpress/9780262035798.001.0001

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Cannabinoids, Body Weight, Feeding, and Appetite

Cannabinoids, Body Weight, Feeding, and Appetite

(p.97) 7 Cannabinoids, Body Weight, Feeding, and Appetite
Cannabinoids and the Brain

Linda A. Parker

The MIT Press

The endcoannabinoid system is an important regulator of appetite, food preference and body weight. It not only regulates metabolic feeding related hormones (leptin, ghrelin) in the brain and gut, but also regulates the brain reward circuitry involved in palatability based feeding. One of the primary roles of the endocannabinoid system is in the homeostatic regulation of feeding behaviour. New treatments for obesity are being developed that attempt to harvest the anti-obesity effects of the CB1 antagonist, rimonabant, but that are devoid of the psychiatric side effects that became clearly known only after it was widely prescribed.

Keywords:   Rimonabant, CB1 antagonist, Anti-obesity, Appetite, Leptin, Ghrelin, Hypothalamus, Cholesystokinin, Eating disorders, cachexia

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