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Cannabinoids and the Brain$
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Linda A. Parker

Print publication date: 2017

Print ISBN-13: 9780262035798

Published to MIT Press Scholarship Online: September 2017

DOI: 10.7551/mitpress/9780262035798.001.0001

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Cannabinoids and Nausea

Cannabinoids and Nausea

(p.107) 8 Cannabinoids and Nausea
Cannabinoids and the Brain

Linda A. Parker

The MIT Press

The treatment of nausea has lagged behind the treatment of chemotherapy-induced vomiting, despite its prevalence. The first recognized medicinal benefit of THC after its discovery was for chemotherapy-induced nausea and vomiting. Since the discovery of the endocannabinoid system, our understanding of the mechanisms by which cannabinoids reduce nausea and vomiting has been greatly improved. CB1 agonists reduce nausea in preclinical models. CBD and CBDA also show promise as non-psychoactive treatments. As well treatments that boost the endogenous cannabinoid system by inhibiting the degrading enzymes FAAH (elevating AEA) and MAGL (elevating 2-AG) or both have shown promise to treat nausea in preclinical models. New research identifies the interoceptive insular cortex as a region which may regulate the experience of nausea and its amelioration by 2-AG.

Keywords:   Nausea, Vomiting, Chemotherapy, Insular cortex

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