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Cannabinoids and the Brain$
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Linda A. Parker

Print publication date: 2017

Print ISBN-13: 9780262035798

Published to MIT Press Scholarship Online: September 2017

DOI: 10.7551/mitpress/9780262035798.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 23 September 2021

Cannabinoids and Epilepsy

Cannabinoids and Epilepsy

Chapter:
(p.139) 10 Cannabinoids and Epilepsy
Source:
Cannabinoids and the Brain
Author(s):

Linda A. Parker

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262035798.003.0010

Cannabis has historically been drug of choice in treating epilepsy, particularly in the 1800’s. However, there have been no modern controlled clinical trials on the effectiveness of cannabis or THC in treating seizures in humans. Preclinical research suggests that CB1 agonists reduce seizures in animal models, however, there is also some evidence that THC may be proconvulsant. It is now known epilepsy can substantially modify the endocannabinoid signalling system, by modifying the relative activation of excitatory glutamate and inhibitory GABA transmission. Considerable recent media interest has focussed on the potential of CBD to reduce seizures in a childhood form of epilepsy called Dravet’s syndrome. The evidence for the anti-convulsant potential of CBD and other cannabinoids is reviewed in this chapter.

Keywords:   Anti-convuslant, GABA, Glutamate, Epilepsy, CBD, Dravet’s syndrome

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