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A New Understanding of Mental DisordersComputational Models for Dimensional Psychiatry$
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Andreas Heinz

Print publication date: 2017

Print ISBN-13: 9780262036894

Published to MIT Press Scholarship Online: May 2018

DOI: 10.7551/mitpress/9780262036894.001.0001

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Serotonergic Neurotransmission and Its Role in Negative Affect

Serotonergic Neurotransmission and Its Role in Negative Affect

(p.55) 5 Serotonergic Neurotransmission and Its Role in Negative Affect
A New Understanding of Mental Disorders

Andreas Heinz

The MIT Press

While dopaminergic neurotransmission has largely been implicated in reinforcement learning and model-based versus model-free decision making, serotonergic neurotransmission has been implicated in encoding aversive outcomes. Accordingly, serotonin dysfunction has been observed in disorders characterized by negative affect including depression, anxiety and addiction. Serotonin dysfunction in these mental disorders is described and its association with negative affect is discussed.

Keywords:   Dopaminergic neurotransmission, Reinforcement learning, Model-based decision, Serotonin dysfunction, Mental disorders, Anxiety, Depression, Addiction, Negative affect

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