Serotonergic Neurotransmission and Its Role in Negative Affect
Serotonergic Neurotransmission and Its Role in Negative Affect
While dopaminergic neurotransmission has largely been implicated in reinforcement learning and model-based versus model-free decision making, serotonergic neurotransmission has been implicated in encoding aversive outcomes. Accordingly, serotonin dysfunction has been observed in disorders characterized by negative affect including depression, anxiety and addiction. Serotonin dysfunction in these mental disorders is described and its association with negative affect is discussed.
Keywords: Dopaminergic neurotransmission, Reinforcement learning, Model-based decision, Serotonin dysfunction, Mental disorders, Anxiety, Depression, Addiction, Negative affect
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