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A New Understanding of Mental DisordersComputational Models for Dimensional Psychiatry$
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Andreas Heinz

Print publication date: 2017

Print ISBN-13: 9780262036894

Published to MIT Press Scholarship Online: May 2018

DOI: 10.7551/mitpress/9780262036894.001.0001

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Learning Mechanisms in Affective Disorders

Learning Mechanisms in Affective Disorders

(p.143) 9 Learning Mechanisms in Affective Disorders
A New Understanding of Mental Disorders

Andreas Heinz

The MIT Press

Affective disorders are described with respect to a model of positive and negative affect, which suggests that clinical depression may result both from an impairment of reward anticipation and experience as well as from an increase in negative affect, which correlates with increased activation of limbic circuits associated with fear and anxiety. Dopamine and serotonin dysfunction interacting with such functional alterations are described, and stress effects on these neurotransmitter systems are discussed. The dimensional approach to affective disorders is explained with respect to different syndrome clusters reflecting negative affect and clinical depression.

Keywords:   Affective disorders, Positive affect, Negative affect, Clinical depression, Reward anticipation, Dopamine, Serotonin dysfunction, Neurotransmitter

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