Learning Mechanisms in Affective Disorders
Learning Mechanisms in Affective Disorders
Affective disorders are described with respect to a model of positive and negative affect, which suggests that clinical depression may result both from an impairment of reward anticipation and experience as well as from an increase in negative affect, which correlates with increased activation of limbic circuits associated with fear and anxiety. Dopamine and serotonin dysfunction interacting with such functional alterations are described, and stress effects on these neurotransmitter systems are discussed. The dimensional approach to affective disorders is explained with respect to different syndrome clusters reflecting negative affect and clinical depression.
Keywords: Affective disorders, Positive affect, Negative affect, Clinical depression, Reward anticipation, Dopamine, Serotonin dysfunction, Neurotransmitter
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