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Combinatorics of Genome Rearrangements$
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Guillaume Fertin, Anthony Labarre, Irena Rusu, Eric Tannier, and Stéphane Vialette

Print publication date: 2009

Print ISBN-13: 9780262062824

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262062824.001.0001

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Paths and Cycles

Paths and Cycles

(p.161) 10 Paths and Cycles
Combinatorics of Genome Rearrangements

Guillaume Fertin

Anthony Labarre

Irena Rusu

Eric Tannier

Steéphane Vialette

The MIT Press

This chapter discusses the modeling of a genome with several chromosomes by a set of paths and cycles. The model captures all the information about the order of the genes and their partition into chromosomes. The discussion covers genomes; breakpoints; intervals; translocation distance; double cut-and-joins (2-break rearrangement); k-break rearrangement; fusions, fissions, translocations, and reversals; and rearrangements with partially ordered chromosomes.

Keywords:   genomes, chromosomes, breakpoints, intervals, translocation distance, double cut-and-joins, reversals

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