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Combinatorics of Genome Rearrangements - MIT Press Scholarship Online
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Combinatorics of Genome Rearrangements

Guillaume Fertin, Anthony Labarre, Irena Rusu, Eric Tannier, and Stéphane Vialette


From one cell to another, from one individual to another, and from one species to another, the content of DNA molecules is often similar. The organization of these molecules, however, differs dramatically, and the mutations that affect this organization are known as genome rearrangements. Combinatorial methods are used to reconstruct putative rearrangement scenarios in order to explain the evolutionary history of a set of species, often formalizing the evolutionary events that can explain the multiple combinations of observed genomes as combinatorial optimization problems. This book offers a c ... More

Keywords: DNA molecules, mutations, genome rearrangements, combinatorial optimization, median problem, phylogenetic trees, cell, species, combinatorial methods, putative rearrangement scenarios

Bibliographic Information

Print publication date: 2009 Print ISBN-13: 9780262062824
Published to MIT Press Scholarship Online: August 2013 DOI:10.7551/mitpress/9780262062824.001.0001


Affiliations are at time of print publication.

Guillaume Fertin, author

Anthony Labarre, author

Irena Rusu, author