- Title Pages
- Preface
- Acknowledgments
- Introduction
-
1 The Early History of Protocells: The Search for the Recipe of Life -
2 Experimental Approaches to Fabricating Artificial Cellular Life -
3 Semisynthetic Minimal Cells: New Advancements and Perspectives -
4 A Roadmap to Protocells -
II INTEGRATION -
5 Steps Toward a Synthetic Protocell -
6 Assembly of a Minimal Protocell -
7 Population Analysis of Liposomes with Protein Synthesis and a Cascading Genetic Network -
8 Constructive Approach to Protocells: Theory and Experiments -
9 Origin of Life and Lattice Artificial Chemistry -
10 Models of Protocell Replication -
11 Compositional Lipid Protocells: Reproduction without Polynucleotides -
12 Evolutionary Microfluidic Complementation Toward Artificial Cells -
III COMPONENTS -
13 Self-Replication and Autocatalysis -
14 Replicator Dynamics in Protocells -
15 Peptide Nucleic Acids as Prebiotic and Abiotic Genetic Material -
16 The Core of a Minimal Gene Set: Insights from Natural Reduced Genomes -
17 Parasitism and Protocells: Tragedy of the Molecular Commons -
18 Forming the Essential Template for Life: The Physics of Lipid Self-Assembly -
19 Numerical Methods for Protocell Simulations -
20 Core Metabolism as a Self-Organized System -
21 Energetics, Energy Flow, and Scaling in Life -
IV BROADER CONTEXT -
22 Gánti’s Chemoton Model and Life Criteria -
23 Viral Individuality and Limitations of the Life Concept -
24 Nonlinear Chemical Dynamics and the Origin of Life: The Inorganic-Physical Chemist Point of View -
25 Early Ancestors of Existing Cells -
26 Prebiotic Chemistry, the Primordial Replicator, and Modern Protocells -
27 Cell-like Entities: Scientific Challenges and Future Applications -
28 Social and Ethical Issues Concerning Protocells - Glossary
- About the Authors
- Index
The Early History of Protocells: The Search for the Recipe of Life
The Early History of Protocells: The Search for the Recipe of Life
- Chapter:
- (p.2) (p.3) 1 The Early History of Protocells: The Search for the Recipe of Life
- Source:
- Protocells
- Author(s):
Martin M. Hanczyc
- Publisher:
- The MIT Press
This book discusses the methods and conditions to produce protocells. The production of a protocell requires the combination of an appropriate mix of nonliving molecules, let them react, and self-assemble in a living protocell. This introduction provides a brief overview of protocells and the scientific roots of contemporary protocell research. It situates protocell science in the broader context of the theories of life, minimal forms of life and the origin of life.
Keywords: protocells, nonliving molecules, protocell research, protocell science, origin of life
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- Title Pages
- Preface
- Acknowledgments
- Introduction
-
1 The Early History of Protocells: The Search for the Recipe of Life -
2 Experimental Approaches to Fabricating Artificial Cellular Life -
3 Semisynthetic Minimal Cells: New Advancements and Perspectives -
4 A Roadmap to Protocells -
II INTEGRATION -
5 Steps Toward a Synthetic Protocell -
6 Assembly of a Minimal Protocell -
7 Population Analysis of Liposomes with Protein Synthesis and a Cascading Genetic Network -
8 Constructive Approach to Protocells: Theory and Experiments -
9 Origin of Life and Lattice Artificial Chemistry -
10 Models of Protocell Replication -
11 Compositional Lipid Protocells: Reproduction without Polynucleotides -
12 Evolutionary Microfluidic Complementation Toward Artificial Cells -
III COMPONENTS -
13 Self-Replication and Autocatalysis -
14 Replicator Dynamics in Protocells -
15 Peptide Nucleic Acids as Prebiotic and Abiotic Genetic Material -
16 The Core of a Minimal Gene Set: Insights from Natural Reduced Genomes -
17 Parasitism and Protocells: Tragedy of the Molecular Commons -
18 Forming the Essential Template for Life: The Physics of Lipid Self-Assembly -
19 Numerical Methods for Protocell Simulations -
20 Core Metabolism as a Self-Organized System -
21 Energetics, Energy Flow, and Scaling in Life -
IV BROADER CONTEXT -
22 Gánti’s Chemoton Model and Life Criteria -
23 Viral Individuality and Limitations of the Life Concept -
24 Nonlinear Chemical Dynamics and the Origin of Life: The Inorganic-Physical Chemist Point of View -
25 Early Ancestors of Existing Cells -
26 Prebiotic Chemistry, the Primordial Replicator, and Modern Protocells -
27 Cell-like Entities: Scientific Challenges and Future Applications -
28 Social and Ethical Issues Concerning Protocells - Glossary
- About the Authors
- Index
