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System Modeling in Cellular BiologyFrom Concepts to Nuts and Bolts$
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System Modeling in Cellular Biology: From Concepts to Nuts and Bolts

Zoltan Szallasi, Jorg Stelling, and Vipul Periwal

Print publication date: 2006

Print ISBN-13: 9780262195485

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262195485.001.0001

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PRINTED FROM MIT PRESS SCHOLARSHIP ONLINE (www.mitpress.universitypressscholarship.com). (c) Copyright The MIT Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in MITSO for personal use.date: 05 August 2021

Using Control Theory to Study Biology*

Using Control Theory to Study Biology*

Chapter:
(p.243) 12 Using Control Theory to Study Biology*
Source:
System Modeling in Cellular Biology
Author(s):

Brian P. Ingalls

Tau-Mu Yi

Pablo A. Iglesias

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262195485.003.0012

This chapter presents a framework ideally suited to an analysis of dynamic systems. Tools from control theory can be applied to elucidate the functioning of self-regulating (homeostatic) systems and to predict the effect of perturbations. It begins with an introduction to the framework of linear systems and one of the primary tools for describing their behavior: the frequency response. It then discusses how one particular type of control system, integral feedback control, plays a crucial role in both homeostasis and sensory adaptation. Next, it considers other uses of feedback mechanisms in cell signaling pathways.

Keywords:   dynamic systems, control theory, self-regulating systems, frequency response, integral feedback control, homeostasis, sensory adaptation, cell signaling pathways

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