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System Modeling in Cellular BiologyFrom Concepts to Nuts and Bolts$
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Zoltan Szallasi, Jorg Stelling, and Vipul Periwal

Print publication date: 2006

Print ISBN-13: 9780262195485

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262195485.001.0001

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Synthetic Gene Regulatory Systems

Synthetic Gene Regulatory Systems

(p.269) 13 Synthetic Gene Regulatory Systems
System Modeling in Cellular Biology

Mads Kærn

Ron Weiss

The MIT Press

This chapter focuses on the mathematical design and experimental implementation of selected synthetic gene regulatory networks that embody important architectural properties. The chapter is organized as follows. Section 13.2 and 13.3 discuss the general aspects of transcriptional regulation and how transcription is modeled, respectively. The remaining sections highlight how synthetic gene regulatory systems have been designed and implemented in the bacterium Escherichia coli based on network models constructed from phenomenological mathematical descriptions of transcriptional regulation. Sections 13.4 and 13.5 discuss linear transcriptional networks and feedforward networks, respectively. Section 13.6 provides examples of networks that support bistability and oscillations by incorporating feedback control. These systems demonstrate how some of the principles investigated in Chapter 6 have been used to create living cells with complex dynamical properties.

Keywords:   selected synthetic gene regulatory networks, transcription regulation, Escherichia coli, linear transcriptional networks, feedforward networks, feedback control

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