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System Modeling in Cellular BiologyFrom Concepts to Nuts and Bolts$
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Zoltan Szallasi, Jorg Stelling, and Vipul Periwal

Print publication date: 2006

Print ISBN-13: 9780262195485

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262195485.001.0001

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Stoichiometric and Constraint-based Modeling

Stoichiometric and Constraint-based Modeling

(p.73) 5. Stoichiometric and Constraint-based Modeling
System Modeling in Cellular Biology

Steffen Klamt

Jörg Stelling

The MIT Press

This chapter explains the main concepts of stoichiometric network analysis (SNA). Stoichiometric modeling has become an important approach for understanding the function of metabolic networks. Hence, the focus is on metabolism, and extensions to cellular regulation are discussed. One aim of the chapter is to review critically virtues and limitations of the approaches with respect to their potential applications for realistic biological networks. It compares four major approaches to SNA by addressing the following issues: network consistency, functional pathways and cycles, network capabilities, importance of reactions, correlated reactions, network design, and network flexibility and robustness.

Keywords:   stoichiometric network analysis, system biology, metabolic networks, metabolism, cellular regulation, biological networks

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