Qualitative Approaches to the Analysis of Genetic Regulatory Networks
Qualitative Approaches to the Analysis of Genetic Regulatory Networks
This chapter discusses three approaches for analyzing qualitative properties of the dynamics of genetic regulatory networks, based on increasingly-abstract modeling formalisms: discrete abstractions of differential equations, Boolean networks, and graphs. Whereas the first two approaches use models that explicitly describe the dynamics of the system, the third approach is based on the assumption that an analysis of the structure of the system provides useful insights into its dynamics. The approaches are illustrated by means of a simple two-gene network and an example of their application to real biological systems.
Keywords: qualitative properties, differential equations, Boolean networks, graphs, two-gene network, biological systems
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