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System Modeling in Cellular BiologyFrom Concepts to Nuts and Bolts$
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Zoltan Szallasi, Jorg Stelling, and Vipul Periwal

Print publication date: 2006

Print ISBN-13: 9780262195485

Published to MIT Press Scholarship Online: August 2013

DOI: 10.7551/mitpress/9780262195485.001.0001

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Qualitative Approaches to the Analysis of Genetic Regulatory Networks

Qualitative Approaches to the Analysis of Genetic Regulatory Networks

Chapter:
(p.125) 7 Qualitative Approaches to the Analysis of Genetic Regulatory Networks
Source:
System Modeling in Cellular Biology
Author(s):

Hidde de Jong

Delphine Ropers

Publisher:
The MIT Press
DOI:10.7551/mitpress/9780262195485.003.0007

This chapter discusses three approaches for analyzing qualitative properties of the dynamics of genetic regulatory networks, based on increasingly-abstract modeling formalisms: discrete abstractions of differential equations, Boolean networks, and graphs. Whereas the first two approaches use models that explicitly describe the dynamics of the system, the third approach is based on the assumption that an analysis of the structure of the system provides useful insights into its dynamics. The approaches are illustrated by means of a simple two-gene network and an example of their application to real biological systems.

Keywords:   qualitative properties, differential equations, Boolean networks, graphs, two-gene network, biological systems

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